Presentation by Dr. Shalender Bhasin

Shalender Bhasin, Endocrinologist and Professor at Harvard Medical School, gave a lecture entitled “Testosterone: Effects on Muscle and Metabolism.” The talk addressed the role of testosterone as a key regulatory hormone in skeletal muscle and systemic metabolism. Testosterone was presented as a central driver of increased muscle mass and strength, while simultaneously contributing to a reduction in fat mass. Drawing on mechanistic and clinical studies, the lecture outlined how testosterone acts through androgen and estrogen receptor–dependent pathways to influence muscle hypertrophy, insulin sensitivity, and energy metabolism. The presentation highlighted long-term research establishing testosterone as an important metabolic messenger and summarized evidence from human studies demonstrating its impact on body composition and metabolic health.

HyperMet research examines the impact of muscle growth (hypertrophy) and muscle loss (atrophy) on metabolism. Increased muscle mass reduces the risk of obesity, diabetes, osteoporosis, and potentially cancer. We are exploring the underlying metabolic processes to develop new strategies for prevention and everyday life.