Input Flux analysis

Sheng Tony Hui gave a HyperMet talk on the 12.06.2025 on “Quantitative flux analysis of energy metabolism in mice” He is an assistant professor of molecular metabolism at Harvard and uses metabolic flux analysis with stable isotope and radioisotope-labelled metabolites to investigate metabolism during exercise, obesity, and cancer cachexia. Tony gave a fantastic talk presenting data obtained with key HyperMet methods.

relevant publications:

Hui, S., Ghergurovich, J., Morscher, R. et al. Glucose feeds the TCA cycle via circulating lactate. Nature 551, 115–118 (2017). https://doi.org/10.1038/nature24057

Bo Yuan, Will Doxsey, Özlem Tok, Young-Yon Kwon, Yanshan Liang, Karen E. Inouye, Gökhan S. Hotamışlıgil, Sheng Hui,
An organism-level quantitative flux model of energy metabolism in mice,
Cell Metabolism, Volume 37, Issue 4, 2025, Pages 1012-1023.e6
https://doi.org/10.1016/j.cmet.2025.01.008

HyperMet research examines the impact of muscle growth (hypertrophy) and muscle loss (atrophy) on metabolism. Increased muscle mass reduces the risk of obesity, diabetes, osteoporosis, and potentially cancer. We are exploring the underlying metabolic processes to develop new strategies for prevention and everyday life.