Human Th1 cell metabolism: Implications for antiviral defense and autoimmunity
By analyzing metabolism of primary human Th1 cells we found an intriguing link between Glycolysis and Interferon γ (IFNg) production. IFNg is an important antiviral cytokine that is regulated by the transcription factor STAT1. Specifically, Glycolysis sustains STAT1 activity via STAT1 O-glycosylation, which is essential for human Th1 cell differentiation and IFNg production by maintaining STAT1 S727 phosphorylation.
www.life-science-alliance.org/content/9/1/e202503315
Life Science Alliance, May 2025: A fluorescent sensor for real-time monitoring of DPP8/9 reveals crucial roles in immunity and cancer
We congratulate Prof. Dirk Mielenz and colleagues from FAU Erlangen on their publication titled: "A fluorescent sensor for real-time monitoring of DPP8/9 reveals crucial roles in immunity and cancer" in the Life Science Alliance journal. In their article, Weiss et al. describe the significance of DPP8/9 activity and introduce a new sensor that enables the measurement of DPP8/9 activity in living cells.
https://www.life-science-alliance.org/content/8/8/e202403076
Nature Immunology Journal, December 2024: Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells
Congratulations to Prof. Dr. Dr. Bertram Bengsch and his team from the University Hospital Freiburg on their publication in the Nature Immunology Journal. Zhang et al. describe the dependence of IL-21 signaling on the efficacy of CTLA4 checkpoint therapy in melanoma.
https://www.nature.com/articles/s41590-024-02027-0
Molecular Metabolism Journal, September 2024: Metabolic profiling of single cells by exploiting NADH and FAD fluorescence via flow cytometry
Congratulations to Prof. Dr. Dirk Mielenz and his team from FAU in Erlangen. In their publication, Abir et al. describe a label-free method to detect metabolic changes by analyzing the redox ratio of FAD/NADH fluorescence in real time in viable cell populations using flow cytometry.
Blood Cancer Journal, August 2024: B cell intrinsic RANK signaling cooperates with TCL1 to induce lineage-dependent B cell transformation
We congratulate PD Dr. Maike Buchner and her team at the Technical University of Munich on their latest publication in the Blood Cancer Journal. In their study, Pfeuffer et al. show interesting data on the influence of RANK signaling on B cell transformation and the tumor microenvironment.